Multiple Adobe products, including (1) Photoshop CS2, (2) Illustrator CS2, and (3) Adobe Help Center, install a large number of .EXE and .DLL files with write-access permission for the Everyone group, which allows local users to gain privileges via Trojan horse programs.
Buffer overflow in a "core application plug-in" for Adobe Reader 5.1 through 7.0.2 and Acrobat 5.0 through 7.0.2 allows attackers to cause a denial of service (crash) and possibly execute arbitrary code via unknown vectors.
The Adobe Reader control in Adobe Reader and Acrobat 7.0 and 7.0.1 allows remote attackers to determine the existence of files via Javascript containing XML script, aka the "XML External Entity vulnerability."