The package python/cpython from 0 and before 3.6.13, from 3.7.0 and before 3.7.10, from 3.8.0 and before 3.8.8, from 3.9.0 and before 3.9.2 are vulnerable to Web Cache Poisoning via urllib.parse.parse_qsl and urllib.parse.parse_qs by using a vector called parameter cloaking. When the attacker can separate query parameters using a semicolon (;), they can cause a difference in the interpretation of the request between the proxy (running with default configuration) and the server. This can result in malicious requests being cached as completely safe ones, as the proxy would usually not see the semicolon as a separator, and therefore would not include it in a cache key of an unkeyed parameter.
http.client in Python 3.x before 3.5.10, 3.6.x before 3.6.12, 3.7.x before 3.7.9, and 3.8.x before 3.8.5 allows CRLF injection if the attacker controls the HTTP request method, as demonstrated by inserting CR and LF control characters in the first argument of HTTPConnection.request.
In Lib/tarfile.py in Python through 3.8.3, an attacker is able to craft a TAR archive leading to an infinite loop when opened by tarfile.open, because _proc_pax lacks header validation.
In Python 3.6 through 3.6.10, 3.7 through 3.7.8, 3.8 through 3.8.4rc1, and 3.9 through 3.9.0b4 on Windows, a Trojan horse python3.dll might be used in cases where CPython is embedded in a native application. This occurs because python3X.dll may use an invalid search path for python3.dll loading (after Py_SetPath has been used). NOTE: this issue CANNOT occur when using python.exe from a standard (non-embedded) Python installation on Windows.
Lib/ipaddress.py in Python through 3.8.3 improperly computes hash values in the IPv4Interface and IPv6Interface classes, which might allow a remote attacker to cause a denial of service if an application is affected by the performance of a dictionary containing IPv4Interface or IPv6Interface objects, and this attacker can cause many dictionary entries to be created. This is fixed in: v3.5.10, v3.5.10rc1; v3.6.12; v3.7.9; v3.8.4, v3.8.4rc1, v3.8.5, v3.8.6, v3.8.6rc1; v3.9.0, v3.9.0b4, v3.9.0b5, v3.9.0rc1, v3.9.0rc2.
Python 2.7 through 2.7.17, 3.5 through 3.5.9, 3.6 through 3.6.10, 3.7 through 3.7.6, and 3.8 through 3.8.1 allows an HTTP server to conduct Regular Expression Denial of Service (ReDoS) attacks against a client because of urllib.request.AbstractBasicAuthHandler catastrophic backtracking.
The CGIHandler class in Python before 2.7.12 does not protect against the HTTP_PROXY variable name clash in a CGI script, which could allow a remote attacker to redirect HTTP requests.
An exploitable denial-of-service vulnerability exists in the X509 certificate parser of Python.org Python 2.7.11 / 3.6.6. A specially crafted X509 certificate can cause a NULL pointer dereference, resulting in a denial of service. An attacker can initiate or accept TLS connections using crafted certificates to trigger this vulnerability.